Tammy - without a photo, I would have to guess that you are referring to a leaf gall, which is perfectly harmless to the tree. Here is an article from Ohio State University about all the galls that can appear on maples, to give you an idea:
http://ohioline.osu.edu/factsheet/ENT-60 Specifically, on willows, I did find this short article with a photo, but can't vouch for the expertise of the writer:
http://www.extension.uidaho.edu/nursery/Landscape%20problems/Willow%20Leaf%20Galls11.pdf Contact your Ohio Extension if you still have concerns!